Drug discovery pipeline 2

• Tyrosine kinase expressed in colon cancer stem cells
• Target+ cells show enhanced proliferation, clonogenicity, migration and tumorigenicity
• mAbs with sub-nM affinity that compete with ligand binding were generated
• Lead optimization started

Project funded by:

• Hormone receptor belonging to GPCR family
• Expressed in subset of lung cancers, including CSCs, expression in other solid tumors documented in literature
• Peptides conjugated to potent drugs hitting CSCs are being developed and will be used for target validation